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DeCS
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Descriptor English:
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Receptors, LDL
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Descriptor Spanish:
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receptores de LDL
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Descriptor Portuguese:
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Receptores de LDL
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Synonyms English:
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LDL Receptor
LDL Receptors
LDL Receptors, Lipoprotein
Lipoprotein LDL Receptors
Low Density Lipoprotein Receptor
Low Density Lipoprotein Receptors
Receptor, LDL
Receptors, Lipoprotein LDL
Receptors, Lipoprotein, LDL
Receptors, Low Density Lipoprotein
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Tree Number:
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D12.776.543.750.710.450
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Definition English:
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Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking. |
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See Related English:
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Lipoproteins, LDL
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History Note English:
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85; LIPOPROTEINS, LDL RECEPTORS was see RECEPTORS, LDL 1985-92
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Allowable Qualifiers English:
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Record Number:
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22650
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Unique Identifier:
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D011973
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Occurrence in VHL:
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Similar:
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DeCS
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